VELPANAT
DESCRIPTION:
Drug profile:
Trade name: Velpanat
Composition: Sofosbuvir & Velpatasvir
Strength of the components: 400mg & 100mg respectively
Manufacturer name: Natco pharma
Package: 28 tablets in a container
Classification: Anti-hepaciviral drug.
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| velpanat tablet |
Drug Prescribing Information of Velpanat tablets:
Velpanat is used in following conditions like;
•Patients with decompensated with long-lasting condition used in combination with ribavirin.
•Patients suffered from compensated cirrhosis or without cirrhosis.
Velpanat tablets are used in the conditions like hepatitis C viral infection in adolescents; HCV infection is caused by various genotypes like I, II, III, IV, V or VI.
Mechanism of Action of Velpanat :
A Velpanat tablet containing directly acting anti-viral agents such as sofosbuvir & Velpatasvir which expels their actions by undergoing some mechanism includes;
Sofosbuvir is an inhibitor of HCV NS5B RNA dependent RNA polymerase, an enzyme essential for viral production. Hence this inhibition causes depletion in viral proliferation.
Velpatasvir is an inhibitor of HCV NS5A is a pan genotype, NS5A is a protein required for HCV viral replication thus the inhibition leads to reduce the production of HCV virus in the human body.
Dosage Regimens of Velpanat tablets:
Before initiating the therapy, patients should be examined by counting the hepatitis B surface antigen and hepatitis B core antibody (HBsAg & Anti-HBc) to prevent the problem like reactivation of HBV infection.
The prescribed dosage of Velpanat tablets includes as;
Velpanat containing fixed-dose combination drugs like 400mg of sofosbuvir and 100mg of Velpatasvir
Recommended Velpanat tablets in patients with chronic HCV infection related to genotypes like I, II, III, IV, V or VI.
Patients with child Pugh A: one tablet of Velpanat should be administered as a single dose.
Patients with chronic cirrhosis or decompensated (child B or C): Velpanat tablets should be combined with ribavirin.
The ribavirin dosage should be administered on the basis of the weight of the patients.
Less than 75kg: 1000mg per day; at least75kg: 1200mg per day.
No dosage adjustment is required for renal impaired patients.
Drug Called side effects:
Some effects may occur during the therapy of Velpanat tablets;
Elevate lipase level
Depression
Headache
Fatigue
Anemia
Nausea
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| velpanat tablet(fatigue) |
Safety Measures:
Ribavirin with Velpanat tablets in chronic condition causes ill to pregnant women cause fetal harm.
Care should be taken in renal and hepatic impaired patients.
Serious bradycardia occurs while combining with amiodarone.
While taking Velpanat tablet some adverse effects occur, to avoid these conditions some precautions should be taken.
After completion of therapy, reactivation of HBV infection occurs in the patients who are co-infected with HCV/HBV infections, to avoid these conditions investigate the patient by measuring HBsAg and anti-HBc.
Reduction in the therapeutic effect of Velpanat tablet, while the concomitant use of Velpanat with P-gp inducers.
Treatment:
Check the crucial manifestations and give adjuvant measures.
The Hemodialysis is another method used in the overdose of Velpanat tablets, can efficiently dispose of the dominant circulating metabolite of sofosbuvir, GS-331007 with eradicating ration of 53%.
Hence Velpatasvir is highly bound to the human plasma protein; it is not cleared by hemodialysis and gives incredible results.
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| velpanat tablet(Hemodialysis) |
FOR MORE INFORMATION:
EMAIL :millionhealthpharmaceuticals@gmail.com
MOBILE :9940472902
WEBSITE URL:https://pillsbag.com/products/velpanat
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